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Original Research
Online Published: 29 Jun 2015
 


EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN.


Abstract
We have shown that the serum zinc++ levels were reduced significantly in 56 hypercholestremic patients p<0.01 when compared to 121 normal controls. The cut off point for abnormal cholesterol level was >250 mg%. Lipotab a Unani coded polypharmaceutical having Nepata hindostana Allium sativum and Curcuma longa as its ingredients was prescribed for 3 months in suitable doses in a follow up study on 13 patients of hypercholestremia with cholesterol level >275 mg%. It reduced the cholesterol level p<0.01 as well as the serum zinc level p<0.05. The maximum daily therapeutic dose of Lipotab was 50 mg/kg orally in humans. The drug showed no mortality up to the dose of 25.6 G/kg P.O. in mice. In isolated Langendorff heart preparation antagonism, by Zn++, of cardiotoxic affect of Cd++, Hg++ and Pb++; elements which are implicated in pathophysiology of Atherosclerosis, was demonstrated. In Anaesthetised dogs Lipotab showed a puissant hypotensive effect when given intravenously in 100 mg/kg doses. The present study thus vindicates a role of Zn++ in Hypercholestremia an essential accompaniment of Human Atherosclerosis and in the mechanism of beneficial hypocholestremic action of Lipotab, a safe Unani formulation.

Key words: EFFICACY, STANDARDISED, UNANI, IPOTAB, HYPERCHOLESTREMIA, ZINC


 
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How to Cite this Article
Pubmed Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN. EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM. J Res Educ Indian Med . 1986; 5(3-4): 49-56.

Web Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN. EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM. https://www.jreim-ayushjournal.com/?mno=193661 [Access: September 14, 2024].

AMA (American Medical Association) Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN. EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM. J Res Educ Indian Med . 1986; 5(3-4): 49-56.


Vancouver/ICMJE Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN. EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM. J Res Educ Indian Med . (1986), [cited September 14, 2024]; 5(3-4): 49-56.


Harvard Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN (1986) EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM. J Res Educ Indian Med , 5 (3-4), 49-56.


Turabian Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN. 1986. EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM. Journal of Research and Education in Indian Medicine, 5 (3-4), 49-56.


Chicago Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN. "EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM." Journal of Research and Education in Indian Medicine 5 (1986), 49-56.


MLA (The Modern Language Association) Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN. "EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM." Journal of Research and Education in Indian Medicine 5.3-4 (1986), 49-56. Print.


APA (American Psychological Association) Style

R.B. ARORA, M.E. HAMDARD, K. KHETERPAL, T. KHANNA, S.U. KHAN, E.A. KHAN (1986) EFFICACY OF A STANDARDISED SAFE UNANI CODED DRUG LIPOTAB IN HYPERCHOLESTREMIA AND INVOLVEMENT OF ELEMENT ZINC IN ITS MECHANISM. Journal of Research and Education in Indian Medicine, 5 (3-4), 49-56.


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