ISSN 0970-7700
 
2020, Vol: 26, Issue: 2
26 / 2Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

1. JREIM Covering Letter and Authors Declaration Form (Section 1-5) Ver. Jan 2021
2. TITLE page - Abstract - References etc-Sections -1 to 6 (NEW 2020-21)
3.JREIM Proforma for Authors CV and Declaration cum Consent Form-Ver-R -151022
4. JREIM Template for Submitting Manuscript in JREIM

Original Research
Online Published: 19 Jun 2015
 


EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR.


Abstract
Inflammation and pain are the most common health problems treated with traditional
remedies which mainly comprise medicinal plants. A number of natural products are used in the
traditional medical systems in many countries. An alternative medicine for the treatment of various
diseases is getting more popular. Many medicinal plants provide relief of symptoms comparable to
that of obtained from allopathic medicines. Therefore agents of natural origin with very little side
effects are required as substitute chemicals therapeutics. The methanolic leaf extract of Cocculus
hirsutus (100 and 200 mg/kg) Linn (Menispermaceae) was investigated for its analgesic and antiinflammatory
effects in animals. The analgesic activity of the methanolic leaf extract of Cocculus
hirsutus was investigated by eddy’s hot plate model and acetic acid induced writhing in mice. Antiinflammatory
activity of Cocculus hirsutus was studied by both in vitro and in vivo models. Human
red blood cells membrane stabilization method was adopted for the in vitro anti-inflammatory activity
and for in vivo, carrageenan induced paw edema and cotton pellet induced granuloma in rats was
employed. In eddy’s hot plate analgesic study, both the doses of Cocculus hirsutus showed
significant (p<0.05 and p<0.01 respectively) analgesic activity. In acetic acid induced writhing model,
the onset of writhing was delayed and duration of writhing was shortened by the methanolic extract
of Cocculus hirsutus. In vitro anti-inflammatory activity of the methanolic leaf extract of
Cocculus hirsutus showed significant anti-inflammatory activity in a concentration dependent manner.
Cocculus hirsutus showed significant anti-inflammatory activity on both carrageenan as well as cotton
pellet induced granuloma models in rats. From the results, it was concluded that the methanolic leaf
extract of Cocculus hirsutus possess analgesic and anti-inflammatory.

Key words: Cocculus hirsutus, Analgesic, Anti-inflammatory, HRBC.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by S. SENGOTTUVELU
Articles by K. RAJESH
Articles by S. HAJA SHERIEF
Articles by R. DURAISAMI
Articles by M. VASUDEVAN
Articles by J. NANDHAKUMAR
Articles by D. KARTHIKEYAN
Articles by T. SIVAKUMAR
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med . 2012; 18(3-4): 175-182.

Web Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. https://www.jreim-ayushjournal.com/?mno=192051 [Access: September 15, 2024].

AMA (American Medical Association) Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med . 2012; 18(3-4): 175-182.


Vancouver/ICMJE Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med . (2012), [cited September 15, 2024]; 18(3-4): 175-182.


Harvard Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR (2012) EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med , 18 (3-4), 175-182.


Turabian Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. 2012. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. Journal of Research and Education in Indian Medicine, 18 (3-4), 175-182.


Chicago Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. "EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES." Journal of Research and Education in Indian Medicine 18 (2012), 175-182.


MLA (The Modern Language Association) Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. "EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES." Journal of Research and Education in Indian Medicine 18.3-4 (2012), 175-182. Print.


APA (American Psychological Association) Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR (2012) EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. Journal of Research and Education in Indian Medicine, 18 (3-4), 175-182.


Author LoginReviewer LoginAbout PublisherEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPrivacy PolicyAdvertising PolicyLicense InformationCopyright Information

About Journal of Research and Education in Indian Medicine

The Journal of Research & Education in Indian Medicine (JREIM) is a quarterly peer-reviewed international journal. JREIM has been established and laun ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Websites
http://www.jreim-ayushjournal.com  and  
​http://www.ejmanager.com/my/jreim 
 

JREIM Head Office
B 29/19 Lanka, PO: BHU, Varanasi-221005 UP (India)   
e-mail:  jreim@ejmanager.com,
Tel: (+91) 9305180763

 

If you need to contact an editor, please use the contact details below:
e-mail: editor@jreim-ayushjournal.com, drlaxmi_ayush_journal@yahoo.com
Tel.: (+91) 9305180763 during office hours (10 AM to 5 PM, Monday to Friday)

Rana Gopal Singh, MD, DM
Editor-in- Chief, Integrative Medicine
 rgsingh@bhu.ac.in, profrgsingh@yahoo.com,  

Suresh Kumar, MD (Ayurveda), PhD
Editor-in- Chief, Ayurveda and Yoga
editor-in-chief@jreim-ayushjournal.com,  prof.suresh.india@gmail.com

Change of Address:
To change address or update your personal information, kindly visit your account (author/reviewer/editor) at http://www.ejmanager.com/my/jreim and update your profile.

If you have further queries, we would be happy to answer those. Please send
your queries to  manager@jreim-ayushjournal.com  or call us on +91 9305180763. 

------------------------

Medical advice:
JREIM (http://www.jreim-ayushjournal.com) does not give medical advice and will not be able to respond to inquiries about specific diseases, medical or surgical conditions, diagnosis, treatments or contact of another person.

Authors Contact:
To contact a author, use the information provided with the manuscript; JREIM will not be able to provide additional details.