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Original Research

Online Publishing Date:
19 / 06 / 2015

 


EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR.


Abstract
Inflammation and pain are the most common health problems treated with traditional
remedies which mainly comprise medicinal plants. A number of natural products are used in the
traditional medical systems in many countries. An alternative medicine for the treatment of various
diseases is getting more popular. Many medicinal plants provide relief of symptoms comparable to
that of obtained from allopathic medicines. Therefore agents of natural origin with very little side
effects are required as substitute chemicals therapeutics. The methanolic leaf extract of Cocculus
hirsutus (100 and 200 mg/kg) Linn (Menispermaceae) was investigated for its analgesic and antiinflammatory
effects in animals. The analgesic activity of the methanolic leaf extract of Cocculus
hirsutus was investigated by eddy’s hot plate model and acetic acid induced writhing in mice. Antiinflammatory
activity of Cocculus hirsutus was studied by both in vitro and in vivo models. Human
red blood cells membrane stabilization method was adopted for the in vitro anti-inflammatory activity
and for in vivo, carrageenan induced paw edema and cotton pellet induced granuloma in rats was
employed. In eddy’s hot plate analgesic study, both the doses of Cocculus hirsutus showed
significant (p<0.05 and p<0.01 respectively) analgesic activity. In acetic acid induced writhing model,
the onset of writhing was delayed and duration of writhing was shortened by the methanolic extract
of Cocculus hirsutus. In vitro anti-inflammatory activity of the methanolic leaf extract of
Cocculus hirsutus showed significant anti-inflammatory activity in a concentration dependent manner.
Cocculus hirsutus showed significant anti-inflammatory activity on both carrageenan as well as cotton
pellet induced granuloma models in rats. From the results, it was concluded that the methanolic leaf
extract of Cocculus hirsutus possess analgesic and anti-inflammatory.

Key words: Cocculus hirsutus, Analgesic, Anti-inflammatory, HRBC.


 
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How to Cite this Article
Pubmed Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med . 2012; 18(3-4): 175-182.

Web Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. https://www.jreim-ayushjournal.com/?mno=192051 [Access: March 12, 2024].

AMA (American Medical Association) Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med . 2012; 18(3-4): 175-182.


Vancouver/ICMJE Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med . (2012), [cited March 12, 2024]; 18(3-4): 175-182.


Harvard Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR (2012) EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. J Res Educ Indian Med , 18 (3-4), 175-182.


Turabian Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. 2012. EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. Journal of Research and Education in Indian Medicine, 18 (3-4), 175-182.


Chicago Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. "EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES." Journal of Research and Education in Indian Medicine 18 (2012), 175-182.


MLA (The Modern Language Association) Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR. "EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES." Journal of Research and Education in Indian Medicine 18.3-4 (2012), 175-182. Print.


APA (American Psychological Association) Style

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR (2012) EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES. Journal of Research and Education in Indian Medicine, 18 (3-4), 175-182.


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