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Original Research
Online Published: 16 Jun 2015
 


EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI.


Abstract
This experiment evaluated the effect of the aqueous extract of Urtica dioica leaves
and the ethanolic extract of Picrorhiza scrophulariiflora rhizome on the glycemic and lipidemic
status in type 1 diabetic model rats. Adult Long Evans male rats, bred at BIRDEM animal house,
Dhaka, Bangladesh were used in this study. Type 1 diabetic model rats were produced with a single
intraperitoneal injection of Streptozotocin using standardized method used in BIRDEM. Serum
glucose was estimated by the glucose-oxidase (GOD-PAP) method, serum lipid profiles (cholesterol,
triglycerides, HDL) were measured by enzymatic colorimetric (cholesterol oxidase / peroxidase)
method. Significant blood glucose lowering effect of U. dioica (p<0.001) and P. scrophulariiflora
(p<0.05) were observed in type 1 diabetic model rats. Body weight was decreased significantly
(p<0.02) in the U. dioica treated group. Triglycerides (TG) and cholesterol level were significantly
low (p<0.01) in the U. dioica treated group. Decreased level of TG and cholesterol were also
observed in P. scrophulariiflora extract treated group, but was not significant. Hence the study
showed that semi-chronic administration of the water extract of U. dioica and the ethanolic extract
of P. scrophulariiflora improved the glycemic and lipidemic status in type 1 diabetic model rats.

Key words: Type 1 diabetes, Streptozotocin, Urtica dioica, Picrorhiza scrophulariiflora, Animal model, Glycemic status, Lipidemic status.


 
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How to Cite this Article
Pubmed Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI. EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS. J Res Educ Indian Med . 2011; 17(3-4): 83-87.

Web Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI. EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS. https://www.jreim-ayushjournal.com/?mno=191779 [Access: September 12, 2024].

AMA (American Medical Association) Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI. EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS. J Res Educ Indian Med . 2011; 17(3-4): 83-87.


Vancouver/ICMJE Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI. EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS. J Res Educ Indian Med . (2011), [cited September 12, 2024]; 17(3-4): 83-87.


Harvard Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI (2011) EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS. J Res Educ Indian Med , 17 (3-4), 83-87.


Turabian Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI. 2011. EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS. Journal of Research and Education in Indian Medicine, 17 (3-4), 83-87.


Chicago Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI. "EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS." Journal of Research and Education in Indian Medicine 17 (2011), 83-87.


MLA (The Modern Language Association) Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI. "EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS." Journal of Research and Education in Indian Medicine 17.3-4 (2011), 83-87. Print.


APA (American Psychological Association) Style

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI (2011) EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS. Journal of Research and Education in Indian Medicine, 17 (3-4), 83-87.


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