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Review Article
Online Published: 13 Apr 2018
 


Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene

Uzma Faridi.


Abstract
L- Menthol is abundantly present monoterpene in nature and is effective against many diseases like microbial infection, inflammation or even in cancer. Many in-vitro anticancer/cytoxocity studies confirm its anticancer potential. Interestingly L-menthol is among the few molecules which show activity against multiple targets especially tubulin polymerization like taxol, topoisomerase inhibition like Camptothecin. Other targets are proteins of cell cycle like cyclin/CDK, P21, P53 or P57, WNT pathway proteins like c-myc, cyclin D1, Ca+2 ion channels, and apoptosis. Although it is activity on in-vivo models is yet to be confirmed. Toxicity of L- menthol on animals is very low. All the studies till now showing that L-menthol can be a very good candidate in anticancer drug discovery as it a works on multiple targets, abundantly available and has very less toxicity towards normal cells.

Key words: L-menthol, Monoterpenes, Anticancer, Multiple targets, In-vitro, Toxicity


 
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Pubmed Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. J Res Educ Indian Med . Online First: 13 Apr, 2018. doi:10.5455/JREIM.82-1457992252

Web Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. https://www.jreim-ayushjournal.com/?mno=222004 [Access: September 13, 2024]. doi:10.5455/JREIM.82-1457992252

AMA (American Medical Association) Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. J Res Educ Indian Med . Online First: 13 Apr, 2018. doi:10.5455/JREIM.82-1457992252


Vancouver/ICMJE Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. J Res Educ Indian Med , [cited September 13, 2024]; Online First: 13 Apr, 2018. doi:10.5455/JREIM.82-1457992252


Harvard Style

Uzma Faridi (0) Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. J Res Educ Indian Med , Online First: 13 Apr, 2018. doi:10.5455/JREIM.82-1457992252


Turabian Style

Uzma Faridi. 0. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. Journal of Research and Education in Indian Medicine, Online First: 13 Apr, 2018. doi:10.5455/JREIM.82-1457992252


Chicago Style

Uzma Faridi. "Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene." Journal of Research and Education in Indian Medicine Online First: 13 Apr, 2018. doi:10.5455/JREIM.82-1457992252


MLA (The Modern Language Association) Style

Uzma Faridi. "Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene." Journal of Research and Education in Indian Medicine Online First: 13 Apr, 2018. Web. 13 Sep 2024 doi:10.5455/JREIM.82-1457992252


APA (American Psychological Association) Style

Uzma Faridi (0) Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. Journal of Research and Education in Indian Medicine, Online First: 13 Apr, 2018. doi:10.5455/JREIM.82-1457992252


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