ISSN 0970-7700
 

Original Research 


FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL

TEJINDER KAUR MARWAHA, KIRAN S BHISE.

Abstract
Background: Commiphora mukul widely known as Guggulu. An ethyl acetate
extract of guggul resin, obtained from Commiphora mukul (Fam.: Burseraceae) known as guggulipid
is official in Indian Pharmacopoeia 1. The active constituent of gugulipid is guggulsterone which
has been found to potently inhibit the activation of nuclear factor-kappaB (NF-kappaB), a critical
regulator of inflammatory responses. Commiphora mukul (Guggul extract) was found to be
efficacious and cheap anti-inflammatory drug with least side effects. Therefore it was selected for
the present study. Objective: Considering the above justification an attempt was made to design
and develop herbal anti-inflammatory topical drug delivery system wherein herbal drug in the form
of emulgel was formulated and its effect was compared to marketed preparation. Method: In the
study, topical emulgel of Commiphora mukul (Guggul extract) was formulated. The optimized
batch was evaluated for %EE and %DR followed by in vivo studies. Result: From the in vitro
studies, formulation S3 showed maximum release of 77.57 % in 6 hrs. The formulation S3 was
comparable with marketed tacrolimus ointment. The results indicated that the optimized batch
containing drug Commiphora mukul (Guggul extract) exhibited good results. Conclusion: Thus, the
results indicate that an effective biphasic herbal anti inflammatory formulation containing Commiphora
mukul (Guggul extract) can be prepared in the form of emulgel.

Key words: Anti inflammatory, Commiphora mukul, Gugulipid, Emulgel


 
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Pubmed Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE. FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL. J Res Educ Indian Med . 2014; 20(2): 75-87.


Web Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE. FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL. https://www.jreim-ayushjournal.com/?mno=191189 [Access: December 05, 2023].


AMA (American Medical Association) Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE. FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL. J Res Educ Indian Med . 2014; 20(2): 75-87.



Vancouver/ICMJE Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE. FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL. J Res Educ Indian Med . (2014), [cited December 05, 2023]; 20(2): 75-87.



Harvard Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE (2014) FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL. J Res Educ Indian Med , 20 (2), 75-87.



Turabian Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE. 2014. FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL. Journal of Research and Education in Indian Medicine, 20 (2), 75-87.



Chicago Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE. "FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL." Journal of Research and Education in Indian Medicine 20 (2014), 75-87.



MLA (The Modern Language Association) Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE. "FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL." Journal of Research and Education in Indian Medicine 20.2 (2014), 75-87. Print.



APA (American Psychological Association) Style

TEJINDER KAUR MARWAHA, KIRAN S BHISE (2014) FORMULATION DESIGN AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF COMMIPHORA MUKUL LOADED EMULGEL. Journal of Research and Education in Indian Medicine, 20 (2), 75-87.