ISSN 0970-7700
 

Review Article 


Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene

Uzma Faridi.

Abstract
L- Menthol is abundantly present monoterpene in nature and is effective against many diseases like microbial infection, inflammation or even in cancer. Many in-vitro anticancer/cytoxocity studies confirm its anticancer potential. Interestingly L-menthol is among the few molecules which show activity against multiple targets especially tubulin polymerization like taxol, topoisomerase inhibition like Camptothecin. Other targets are proteins of cell cycle like cyclin/CDK, P21, P53 or P57, WNT pathway proteins like c-myc, cyclin D1, Ca+2 ion channels, and apoptosis. Although it is activity on in-vivo models is yet to be confirmed. Toxicity of L- menthol on animals is very low. All the studies till now showing that L-menthol can be a very good candidate in anticancer drug discovery as it a works on multiple targets, abundantly available and has very less toxicity towards normal cells.

Key words: L-menthol, Monoterpenes, Anticancer, Multiple targets, In-vitro, Toxicity


 
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Pubmed Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. doi:10.5455/JREIM.82-1457992252


Web Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. http://www.jreim-ayushjournal.com/?mno=222004 [Access: April 29, 2020]. doi:10.5455/JREIM.82-1457992252


AMA (American Medical Association) Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. doi:10.5455/JREIM.82-1457992252



Vancouver/ICMJE Style

Uzma Faridi. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. doi:10.5455/JREIM.82-1457992252



Harvard Style

Uzma Faridi (0) Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. doi:10.5455/JREIM.82-1457992252



Turabian Style

Uzma Faridi. 0. Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. doi:10.5455/JREIM.82-1457992252



Chicago Style

Uzma Faridi. "Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene." doi:10.5455/JREIM.82-1457992252



MLA (The Modern Language Association) Style

Uzma Faridi. "Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene." doi:10.5455/JREIM.82-1457992252



APA (American Psychological Association) Style

Uzma Faridi (0) Mechanism of action: L- Menthol a naturally occurring anticancer monoterpene. doi:10.5455/JREIM.82-1457992252





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