Abstract
Introduction: Rasasindura (RS) is a sublimated mercurial preparation known for its
use in different formulations. The efficacy of RS will enhance with the quantity of sulphur and
duration of heating, hence Shadguna Rasa Sindura (SRS) (1:6 proportion of Hg:S) is said to be
superior. Objective: Present study attempts to standardize mode of preparation of SRS & analyse
its physico-chemical properties. Methodology: Shodhita Parada (Purified mercury) and Gandhaka
(sulphur) were triturated till formation of Kajjali (black sulphide devoid of shine) and was
impregnated with Aloe vera Linn. Thus formed Kajjali was placed in Kacha Kupi (glass bottle)
coated with ten layers of cloth and multani mitti. Bottle was placed in Electrical Muffle Furnace
(EMF) and heat was given for 168 hours with Kramagni (gradual rise in temperature). After
observing all chief desired characteristics in process, bottle was sealed and allowed for sublimation
and thus formed product was carefully collected. Same way three batches of SRS were prepared
to ensure standardization and reproducibility. Final product was screened for physico-chemical
analysis. Results: Average yield of SRS was 12.45% and physico-chemical analysis revealed
following results: Loss on drying-0.4, Ash value-0.23, Total Mercury-85.84% and Total Sulphur-
13.07%. Conclusion: SRS can be prepared by adopting 168 hrs of gradual rise in temperature,
i.e. Mild (1200C-2500C), Moderate (2500C-4500C) and Stern (4500C-6000C) temperature. Average
yield of Shadguna RS is 12.45% in EMF. 85.84% of Mercury and 13.07% of Sulphur was detected
in SRS.

Key words: Kupipakwa Rasayana, Shadguna Rasasindura, Standardization.